05-17-2007, 01:39 PM | #81 |
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Re: On Drug Use
I'm considering buying LSD. What are some things I should do to ensure that what I'm buying is worth it? Tests, etc. This will also be my first trip, I understand that I am risking a bad one and have read everything about the drug. Any tips?
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05-17-2007, 02:10 PM | #82 | |
Very Grave Indeed
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Re: On Drug Use
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Yes: Tip 1: Asking in a public forum for information about illegal goods is not a very smart plan. Actually I guess it was just the one tip. |
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05-17-2007, 04:46 PM | #83 | ||||||||||
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Re: On Drug Use
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In general, neural cell damage can be detected by two techniques, using silver staining and measuring the expression of glilal fibrillary acidic protein (GFAP). Not all neurotoxic regimens using MDMA are able to demonstrate increased silver staining or GFAP expression. These techniques seem to detect MDMA-induced alterations only at doses higher than those needed to affect serotonergic function (Commins, 1987; O'Callaghan, 1993). Furthermore, the MDMA-induced cell damage detected by silver staining appears to occur in nonserotonergic cells (Commins, 1987; Jensen, 1993) as well as in what are likely serotonergic axons (Scallet, 1988). These inconsistencies are difficult to interpret. Some believe they are evidence that MDMA-induced serotonergic changes result from down regulation of the serotonergic system rather than damage (e.g., O'Callaghan, 2001). Others have argued that the techniques for measuring cell damage are simply insensitive to selective serotonergic damage (Axt, 1994; Bendotti, 1994; Wilson, 1994). Because studies of axonal transport and VMAT2 changes have provided strong evidence of MDMA-induced axonal damage, it appears that serotonergic down regulation can no longer fully explain the long-term effects of MDMA. Structural changes to serotonergic axons must also be explained. Although we are not aware that this hypothesis has been advanced, one could argue that loss of axons represents a non-neurotoxic form of neuroplasticity, or benign change in the nerve cell in response to drugs. Non-neurotoxic (though not necessarily beneficial) morphological changes can occur in the CNS as the result of alterations in serotonin levels (reviewed in Azmitia 1999). It appears more likely, however, that these changes are, in fact, the result of damage, specifically damage involving oxidative stress. Solution: Take an aspirin when you roll. Amphetamine metabolization causes free radicals to be released which causes oxidative stress. Taking antioxidants alongside MDMA, then, should reduce the damage it does. The axotomy doesn't appear to be caused by down-regulation of sertonin due to MDMA because it not only affects serotonergic cells; it appears that it's caused by oxidative stress. Therefore, take an antioxidant to limit this damage. Logically, using MDMA all the time is going to shock your body into serotonin down-regulation; however, contrary to Ricuarte's horrible study, no sound evidence has been presented which demonstrates that occasional (more than a month between usage) doses cause lasting effects on serotonin that are not reregulated over the course of a week or two. In fact, a few chemists producing MDMA are kind enough to put aspirin inside of their rolls. It's good to know that a few are fighting on the good side while most of the idiots out there are loading their pills up with meth and other horrible junk. Quote:
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In Virginia, anyone over 18 can carry a gun. In Maryland, it requires a permit. In 2003, 413 people were killed by gun violence in Virginia, a death rate of 5.6 per 100,000 inhabitants. By contrast, 525 people were killed in Maryland, a death rate of 9.5 per 100,000 inhabitants In 2004, the rates were 9.4 and 5.2 respectively, demonstrating a carryover in the trend. (FBI, Table 5). Additionally, there's the case of Kennesaw, Georgia. This town requires every able resident to own a gun. Oddly enough, signs seem to attribute a decrease in gun-related crime sense then (wiki link). Of course, the other side of data analysis shows a statistically insignificant increase. I'm not on campus so I can't go to a library to check their methodology (i.e. choosing something absurd like a p = .001 level to test for significance), but both of these point to gun ownership not showing demonstrable positive correlation to shootings. Quote:
If one has a fear of the unknown then he or she has two options: Make it a known or stay away from it. A fear of the unknown doesn't mean this person now has the right to map their fear onto other people, it means they possess an ignorance that stops where their consciousness ends. They have no right to extend their judgment of this unknown past the bounds of their consciousness. Quote:
It's drug misinformation that is causing much of the problems with drug use. The drug 'education' we have today is counterproductive because it is so grossly incorrect. It's not a challenge to educate us about drugs, the powers that be are instead choosing to miseducate us because they're ignorant enough to believe that scare tactics are effective. I'd wager that our youth would be better off if they chose not to listen to the DARE bile, because then maybe they'd take what they hear from other sources in the media to heart when they hear about the dangers of stuff like methamphetamine and heroin. Quote:
"Then there's everyone else, who, if they had the time and urge to, would learn about them. But that would require, as I said, time." That's what school is for; we have 18 years to teach them. If that's not enough time, then I have no idea what is.
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05-17-2007, 05:06 PM | #84 | |
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Re: On Drug Use
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For the trip itself, make sure you go into it with a proper mindset and are in a comfortable setting with which you are familiar. Turn off your phone and make sure that you won't be around anyone who can't know that you are tripping. Have some music you like prepared beforehand. Though I don't usually place much emphasis on music while tripping, something like it or a videogame can be a good way to distract myself if the trip gets intense or I don't like where it is going (The Legend of Zelda & Secret of Mana on acid = A+). Acid works by heightening neural responses, so be prepared for your sensations and emotions to feel amplified and intense. Sometimes, just touching something can be so intense that I can't tell whether I'm feeling pain or the nerves are just incredibly excited. Your emotional responses to things will also be similarly amplified, so if you feel your emotions running out of control, take some time to try to ground yourself and think about how it is just the result of a drug that has modified your perception of reality. (This could even lead into some fun thinking about how arbitrary our perception of reality is too... If you're a philosophical tripper.) I'd recommend 2 hits as a starting dose (two perforated squares). And as a personal recommendation, I thoroughly enjoyed watching the movie Adaptation on the comedown of one of my trips. (Although there is a scene with a person's head split open on the ground that can be a bit intense). It's a very good flavor of movie for a trip if you want some kind of entertainment media.
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05-17-2007, 05:21 PM | #85 |
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Re: On Drug Use
This is besides what I said before but I was wondering where steroids would fall under this topic like questions about legality and safety, not that I'm going to try them haha.
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05-17-2007, 09:55 PM | #86 | ||||||||||
sunshine and rainbows
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Re: On Drug Use
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Hard as it seems for you to believe, YES, I think that in this case, it is best for us to be pawns of society. YOUR, not OUR framework stresses an individual framework for happiness. My framework stresses happiness for as many people as possible. It's messed when the individualistic society goes against someone's personal beliefs because their beliefs aren't individualistic. Quote:
I wasn't trying to say that fear is a good reason, or that even societal values are a good reason. I was just pointing out that there ARE reasons why people say all drugs are bad, beyond ignorance of what's known. Quote:
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Grrr, strong individualism is a damning concept which makes people think that they can do whatever the hell they want whenever they want without looking at the consequences to other people. Geezuz, your "But it's my right" argument could be used for companies who use sweatshops! If the workers are stupid enough to work there, let them! It's my right to make as much money as I possibly can! It's analogous in that someone gains, while someone loses. It's not analogous in that you don't gain directly from the other person's loss, however, in the drug instance, you would indirectly be causing harm. If your argument stands for all drugs, then I can't agree with you. And I don't think guns should be legal either, speaking of accomodating for fearfulness. Do you think nukes should be legal? For the record, I'd rather be happy and immobile than terribly depressed, which would probably make me near immobile as I'd spend all my time in bed, and then probably kill myself. You're talking to a 24 year old, and I'd have to research the stuff myself. A large amount of the population is over 18 you know. You've also not addressed the issue that who I *think* the majority of problem drug users are, are the ones who don't particularly pay attention in school, or even stay in school. Furthermore, drugs are far from static. In order to use safely, unless keeping to the same stuff you've always used, you'd have to learn about each new one, and that takes time and effort. Last edited by Cavernio; 05-17-2007 at 10:01 PM.. |
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05-18-2007, 06:03 PM | #87 | |
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Re: On Drug Use
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If people want to ruin their lives, that's their own business. As long as they aren't hurting anyone else, why should anyone care? And another mostly related statement- Drugs should be made legal. The government could make SOOOO much money on the taxes, and it's not as if it being illegal is the reason people have chosen not to do drugs. In fact, the thrill of going against the law is probably a main reason people try drugs. If they were legal, they could be regulated and the amount of usage would probably go down. |
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05-18-2007, 06:59 PM | #88 | |
Very Grave Indeed
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Re: On Drug Use
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It is only worth the government's time to make something legal with the intention of taxing it, if it is the case that people can't make their own relatively easily. If the more "mild" drugs, like marijuana were legalized, the government would make almost nothing out of it, because it is so cheap and easy to just grow and make all on your own. It's one of the reasons why alcohol is legal. To make most kinda of alcohol takes sophisticated enough equipment and work to produce that the vast majority of people interested in getting it will be inclined to buy it from the government-approved sources rather than make their own. Also..."Because they could make lots of tax revenue" is a terrible reason to make something legal, at least, on its own it is a terrible reason. They could make bloodsport, prostitution, and child abuse legal, provide government operated places to do them, and rake in plenty of revenue, that doesn't mean they ought to. |
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05-21-2007, 12:06 AM | #89 | |
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Re: On Drug Use
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In my opinion, I still think the same about drug users, 90% of them are low-lifes. Even though all of this is probably true, I'll bet that less than 1% of drug users know it. Most use drugs to ease pain and stress, or to "fit in," not because it's a natural and fun thing to do. |
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05-21-2007, 03:45 AM | #90 | |
(The Fat's Sabobah)
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Re: On Drug Use
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05-21-2007, 07:59 AM | #91 | ||
sunshine and rainbows
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Re: On Drug Use
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05-21-2007, 08:05 AM | #92 |
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Re: On Drug Use
weed isnt bad lol
you never hear about anyone OD'ing on weed they just sleepin side effects for weed are Hungry, happy, and sleepy. take tylenol for example, totallylegal, take 13 of them motha****as and thatll be the last headache you ever get |
05-21-2007, 08:21 AM | #93 |
Banned
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Re: On Drug Use
I can tell you smoke a lot. Ya.
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