[Reach]

If you want to zone jobs next to residential, you need to zone offices. Putting things near factories is a recipe for disaster, as there aren't a lot of good ways to minimize ground pollution around industrial zones. It will also be extraordinarily hard to get decent land values or happiness.

You can create symmetrical / mathematical / etc cities, just block your industry outside of those areas, or don't use industry at all once you get offices. Industry drives commercial demand though, so it's nice to have it, but creating a residential / office city is easily possible (See my NYC).