[supermousie]

Originally Posted by ~kitty~

I've never watched this before, but I have heard about it vaguely. I kind of want to see what it's like, but before I watch any of it, what kind of knowledge would you say I would need to have to understand the references and jokes they make? I would like to not be lost, because I would definitely not want to overshoot my own knowledge and assume I already know enough when obviously I'm really just a lazy person and lack a lot in some areas of knowledge (and excel in others).

You don't need a PhD in theoretical physics to watch the show, but it's better to at least have a rudimentary knowledge of the basics to get most of the jokes. If you paid attention in high-school physics, you should be fine.
There are also jokes about computing, and well-known experiments and theories such as Schrodinger's cat, which is sort of a recurring thing.